A Yeast Bioassay for Androgenic and Anti-Androgenic Compounds Based on the NH2- and COOH-Terminal Interaction of Androgen Receptor

Masahiro OGAWA; Ryoichi YAMAJI; Takakazu MITANI; Yohei MURATA; Motoyuki NAKAO; Naoki HARADA; Yoshihisa NAKANO; Hiroshi INUI

doi:10.1271/bbb.100323

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A Yeast Bioassay for Androgenic and Anti-Androgenic Compounds Based on the NH₂- and COOH-Terminal Interaction of Androgen Receptor

Masahiro OGAWA, Ryoichi YAMAJI, Takakazu MITANI, Yohei MURATA, Motoyuki NAKAO, Naoki HARADA, Yoshihisa NAKANO, Hiroshi INUI

著者情報

キーワード: androgen receptor (AR), bioassay, N–C interaction, β-catenin, yeast two-hybrid

ジャーナルフリー早期公開

論文ID: 100323

DOI https://doi.org/10.1271/bbb.100323

この記事には本公開記事があります。

The final version of this article is now available: Vol. 74 (2010) , No. 9 p.1965

詳細

抄録

Androgenic compounds induce an interaction between the NH₂- and COOH-terminal regions (N–C interaction) of androgen receptor (AR). We describe a rapid yeast bioassay for androgenic and anti-androgenic compounds based on androgen-dependent β-catenin-enhanced N–C interaction. The bioassay was also effective at detecting compounds that inhibit the N–C interaction in ways that do not involve binding to the ligand-binding domain.

責任著者(Corresponding author)

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