Drosophila Nucleostemin 2 Proved Essential for Early Eye Development and Cell Survival

Eriko MATSUO; Shuhei KANNO; Shogo MATSUMOTO; Kazuhide TSUNEIZUMI

doi:10.1271/bbb.100386

This article has now been updated. Please use the final version.

Drosophila Nucleostemin 2 Proved Essential for Early Eye Development and Cell Survival

Eriko MATSUO, Shuhei KANNO, Shogo MATSUMOTO, Kazuhide TSUNEIZUMI

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Keywords: Drosophila, nucleostemin, cell death, GTP-binding protein, eye development

JOURNAL FREE ACCESS Advance online publication

Article ID: 100386

DOI https://doi.org/10.1271/bbb.100386

The final version of this article is now available: Vol. 74 (2010) , No. 10 p.2120

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Abstract

Human nucleostemin (NS) is a nucleolar protein involved in cell-cycle progression and ribosomal biogenesis. While four NS orthologs have been reported in Drosophila melanogaster, their roles in development have yet to be determined. Here we describe evidence that Drosophila nucleostemin 2 (ns2) plays a significant role in early eye development and is essential for cell survival in vivo.

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