Drosophila Nucleostemin 2 Proved Essential for Early Eye Development and Cell Survival

Eriko MATSUO; Shuhei KANNO; Shogo MATSUMOTO; Kazuhide TSUNEIZUMI

doi:10.1271/bbb.100386

Biochemistry & Molecular Biology Notes

Drosophila Nucleostemin 2 Proved Essential for Early Eye Development and Cell Survival

Eriko MATSUO, Shuhei KANNO, Shogo MATSUMOTO, Kazuhide TSUNEIZUMI

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Keywords: Drosophila, nucleostemin, cell death, GTP-binding protein, eye development

JOURNAL FREE ACCESS

2010 Volume 74 Issue 10 Pages 2120-2123

DOI https://doi.org/10.1271/bbb.100386

View "Advance Publication" version (October 7, 2010).

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Abstract

Human nucleostemin (NS) is a nucleolar protein involved in cell-cycle progression and ribosomal biogenesis. While four NS orthologs have been reported in Drosophila melanogaster, their roles in development have yet to be determined. Here we describe evidence that Drosophila nucleostemin 2 (ns2) plays a significant role in early eye development and is essential for cell survival in vivo.

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