Overexpression of Transglutaminase in the Drosophila Wing Imaginal Disc Induced an Extra Wing Crossvein Phenotype

Akira ICHIKAWA; Ayako YAMADA; Harunobu SAKAMOTO; Masaru UMEHARA; Yasuhide YOSHIOKA; Masamitsu YAMAGUCHI; Koji IKURA

doi:10.1271/bbb.100449

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Overexpression of Transglutaminase in the Drosophila Wing Imaginal Disc Induced an Extra Wing Crossvein Phenotype

Akira ICHIKAWA, Ayako YAMADA, Harunobu SAKAMOTO, Masaru UMEHARA, Yasuhide YOSHIOKA, Masamitsu YAMAGUCHI, Koji IKURA

著者情報

キーワード: transglutaminase, Drosophila, wing development, wing crossvein, epidermal growth factor receptor (Egfr) signaling pathway

ジャーナルフリー早期公開

論文ID: 100449

DOI https://doi.org/10.1271/bbb.100449

この記事には本公開記事があります。

The final version of this article is now available: Vol. 74 (2010) , No. 12 p.2494

詳細

抄録

To determine the roles of Drosophila transglutaminase-A (dTG-A), we examined a phenotype induced through ectopic expression of dTG-A. Overexpression of dTG-A in the wing imaginal disc induced an extra wing crossvein phenotype. This phenotype was suppressed by crossing with epidermal growth factor receptor (Egfr) signaling pathway mutant flies. These results indicate that this phenotype, induced by dTG-A, is related to enhancement of the Egfr signaling pathway.

責任著者(Corresponding author)

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