Fast and Reliable Determination of Voriconazole in Human Plasma by LC-APCI-MS/MS

Xin XIONG; Jingli DUAN; Suodi ZHAI; Lijue WANG; Xi LAN

doi:10.1271/bbb.100474

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Fast and Reliable Determination of Voriconazole in Human Plasma by LC-APCI-MS/MS

Xin XIONG, Jingli DUAN, Suodi ZHAI, Lijue WANG, Xi LAN

著者情報

キーワード: voriconazole, liquid chromatography coupled with atmospheric pressure chemical ionization tandem mass spectrometry (LC-APCI-MS/MS), human plasma

ジャーナルフリー早期公開

論文ID: 100474

DOI https://doi.org/10.1271/bbb.100474

この記事には本公開記事があります。

The final version of this article is now available: Vol. 74 (2010) , No. 10 p.2151

詳細

抄録

A fast and reliable liquid chromatography coupled with atmospheric pressure chemical ionization tandem mass spectrometry (LC-APCI-MS/MS) method was developed and validated for the quantification of voriconazole in human plasma. The proposed method was validated in a linear range of 50–10,000 ng/ml, and the total run time was 1.5 min. This method was successfully used to support routine therapeutic drug monitoring of voriconazole.

責任著者(Corresponding author)

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