In Vivo Anti-Tumor Activity of a New Doxorubicin Conjugate via α-Linolenic Acid

Menglei HUAN; Han CUI; Zenghui TENG; Bangle ZHANG; Jieping WANG; Xinyou LIU; Hui XIA; Siyuan ZHOU; Qibing MEI

doi:10.1271/bbb.120256

この記事には本公開記事があります。本公開記事を参照してください。
引用する場合も本公開記事を引用してください。

In Vivo Anti-Tumor Activity of a New Doxorubicin Conjugate via α-Linolenic Acid

Menglei HUAN, Han CUI, Zenghui TENG, Bangle ZHANG, Jieping WANG, Xinyou LIU, Hui XIA, Siyuan ZHOU, Qibing MEI

著者情報

キーワード: doxorubicin, α-linolenic acid, prodrug, anti-tumor

ジャーナルフリー早期公開

論文ID: 120256

DOI https://doi.org/10.1271/bbb.120256

この記事には本公開記事があります。

The final version of this article is now available: Vol. 76 (2012) , No. 8 p.1577

詳細

抄録

The conventional chemotherapy agent, doxorubicin, is of limited clinical use because of its systemic toxicity toward normal healthy tissue. A new doxorubicin conjugate with α-linolenic acid showed good anti-tumor activity with lower toxicity than free doxorubicin and exhibited an active tumor-targeting profile due to the introduction of α-linolenic acid which might be an effective tumor-targeting moiety for the modification of chemotherapeutics.

責任著者(Corresponding author)

J-STAGEへの登録はこちら（無料）