Functional Expression of Schizosaccharomyces pombe Vba2p in the Vacuolar Membrane of Saccharomyces cerevisiae

Pongsanat PONGCHAROEN; Miyuki KAWANO-KAWADA; Tomoko IWAKI; Naoko SUGIMOTO; Takayuki SEKITO; Koichi AKIYAMA; Kaoru TAKEGAWA; Yoshimi KAKINUMA

doi:10.1271/bbb.130387

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Functional Expression of Schizosaccharomyces pombe Vba2p in the Vacuolar Membrane of Saccharomyces cerevisiae

Pongsanat PONGCHAROEN, Miyuki KAWANO-KAWADA, Tomoko IWAKI, Naoko SUGIMOTO, Takayuki SEKITO, Koichi AKIYAMA, Kaoru TAKEGAWA, Yoshimi KAKINUMA

著者情報

キーワード: vacuole, transport, lysine, quinidine

ジャーナルフリー早期公開

論文ID: 130387

DOI https://doi.org/10.1271/bbb.130387

この記事には本公開記事があります。

The final version of this article is now available: Vol. 77 (2013), No. 9 pp. 1988-1990

詳細

抄録

A vacuolar membrane protein, Vba2p of Schizosaccharomyces pombe, is involved in basic amino acid uptake by intact cells. Here we found evidence that Vba2p mediated ATP-dependent lysine uptake by vacuolar membrane vesicles of Saccharomyces cerevisiae. Vba2p was also responsible for quinidine sensitivity, and the addition of lysine improved cell growth on quinidine-containing media. These findings should be useful for further characterization of Vba2p.

責任著者(Corresponding author)

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