Induction of Apoptosis in DLD-1 Human Colon Cancer Cells by Peridinin Isolated from the Dinoflagellate, Heterocapsa triquetra

Tatsuya SUGAWARA; Kyoko YAMASHITA; Shota SAKAI; Akira ASAI; Akihiko NAGAO; Tomotaka SHIRAISHI; Ichiro IMAI; Takashi HIRATA

doi:10.1271/bbb.60597

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Induction of Apoptosis in DLD-1 Human Colon Cancer Cells by Peridinin Isolated from the Dinoflagellate, Heterocapsa triquetra

Tatsuya SUGAWARA, Kyoko YAMASHITA, Shota SAKAI, Akira ASAI, Akihiko NAGAO, Tomotaka SHIRAISHI, Ichiro IMAI, Takashi HIRATA

著者情報

キーワード: apoptosis, carotenoids, colon cancer cells, dinoflagellate, peridinin

ジャーナルフリー早期公開

論文ID: 60597

DOI https://doi.org/10.1271/bbb.60597

この記事には本公開記事があります。

The final version of this article is now available: Vol. 71 (2007) , No. 4 p.1069

詳細

抄録

Peridinin, which is uniquely present in dinoflagellates, is one of the most abundant carotenoids found in nature. We evaluated the apoptotic effect of peridinin on DLD-1 human colorectal cancer cells. Peridinin significantly reduced the cell viability in a dose-dependent manner (0–20 μM) and induced apoptosis by activating both caspase-8 and caspase-9. Our findings could be important for the high-performance utilization of marine bioproducts.

責任著者(Corresponding author)

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