Cadmium Cation Increases the Production and mRNA Levels of Insulin-Like Growth Factor-Binding Protein-1 in HepG2

Yuichi OISHI; Motoko OHNISHI; Kazuo KOBAYASHI-HATTORI; Toshichika TAKITA; Tadashi NOGUCHI

doi:10.1271/bbb.60679

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Cadmium Cation Increases the Production and mRNA Levels of Insulin-Like Growth Factor-Binding Protein-1 in HepG2

Yuichi OISHI, Motoko OHNISHI, Kazuo KOBAYASHI-HATTORI, Toshichika TAKITA, Tadashi NOGUCHI

著者情報

キーワード: insulin-like growth factor-binding protein-1 (IGFBP-1), cadmium cation, HepG2

ジャーナルフリー早期公開

論文ID: 60679

DOI https://doi.org/10.1271/bbb.60679

この記事には本公開記事があります。

The final version of this article is now available: Vol. 71 (2007) , No. 5 p.1334

詳細

抄録

The production of insulin-like growth factor-binding protein-1 (IGFBP-1) in HepG2 was increased by cadmium cation (Cd²⁺) at 3 μM, but not by other divalent cations. The mRNA level of IGFBP-1 was also increased by the administration of 3 μM of Cd²⁺. These results suggest that Cd²⁺ impacts the gene expression of IGFBP-1, which leads to production of IGFBP-1.

責任著者(Corresponding author)

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