First Stereoselective Synthesis of meso-Secoisolariciresinol and Comparison of Its Biological Activity with (+) and (−)-Secoisolariciresinol

Takuya SUGAHARA; Satoshi YAMAUCHI; Ai KONDO; Fumi OHNO; Siori TOMINAGA; Yuki NAKASHIMA; Taro KISHIDA; Koichi AKIYAMA; Masafumi MARUYAMA

doi:10.1271/bbb.70358

この記事には本公開記事があります。本公開記事を参照してください。
引用する場合も本公開記事を引用してください。

First Stereoselective Synthesis of meso-Secoisolariciresinol and Comparison of Its Biological Activity with (+) and (−)-Secoisolariciresinol

Takuya SUGAHARA, Satoshi YAMAUCHI, Ai KONDO, Fumi OHNO, Siori TOMINAGA, Yuki NAKASHIMA, Taro KISHIDA, Koichi AKIYAMA, Masafumi MARUYAMA

著者情報

キーワード: lignan, immunosuppressive activity, cytotoxic activity

ジャーナルフリー早期公開

論文ID: 70358

DOI https://doi.org/10.1271/bbb.70358

この記事には本公開記事があります。

The final version of this article is now available: Vol. 71 (2007) , No. 12 p.2962

詳細

抄録

The first stereoselective synthesis of meso-secoisolariciresinol is reported. A comparison of the cytotoxic and immunosuppressive activity between meso-secoisolariciresinol and optically active secoisolariciresinols was similarly performed for the first time. Both enantiomers of secoisolariciresinol accelerated IgM production, although meso-secoisolariciresinol did not affect IgM production. Only meso-secoisolariciresinol showed cytotoxic activity.

責任著者(Corresponding author)

J-STAGEへの登録はこちら（無料）