Identification and Characterization of Mouse Type II Platelet-Derived Growth Factor Receptor α Transcript

Yusuke MINATO; Yoshiaki NIHEI; Yuki KODAMA; Etsu TASHIRO; Mai KANAI; Masaya IMOTO

doi:10.1271/bbb.70640

この記事には本公開記事があります。本公開記事を参照してください。
引用する場合も本公開記事を引用してください。

Identification and Characterization of Mouse Type II Platelet-Derived Growth Factor Receptor α Transcript

Yusuke MINATO, Yoshiaki NIHEI, Yuki KODAMA, Etsu TASHIRO, Mai KANAI, Masaya IMOTO

著者情報

キーワード: platelet-derived growth factor receptor α, E2F-1, transcript variant, alternate promoter, transcriptional regulation

ジャーナルフリー早期公開

論文ID: 70640

DOI https://doi.org/10.1271/bbb.70640

この記事には本公開記事があります。

The final version of this article is now available: Vol. 72 (2008) , No. 3 p.759

詳細

抄録

Recently, we identified a novel human platelet-derived growth factor (PDGF) receptor α mRNA (type II) that differs from the known human PDGF receptor α mRNA (type I) only in its 5′-untranslated region and is regulated by E2F-1. In this study, we determined the nucleotide sequence of the mouse type II PDGF receptor α mRNA and found that the expression of this transcript was regulated by E2F-1 through an E2F-1-responsive sequence located +711/+718 downstream of the transcription start site of the type I transcript. Furthermore, we observed embryo-predominant expression of the type II transcript.

責任著者(Corresponding author)

J-STAGEへの登録はこちら（無料）