Validation of an Ion Trap Tandem Mass Spectrometric Analysis of Mulberry 1-Deoxynojirimycin in Human Plasma: Application to Pharmacokinetic Studies

Kiyotaka NAKAGAWA; Hiroyuki KUBOTA; Tsuyoshi TSUZUKI; Jun KARIYA; Toshiyuki KIMURA; Shinichi OIKAWA; Teruo MIYAZAWA

doi:10.1271/bbb.80200

この記事には本公開記事があります。本公開記事を参照してください。
引用する場合も本公開記事を引用してください。

Validation of an Ion Trap Tandem Mass Spectrometric Analysis of Mulberry 1-Deoxynojirimycin in Human Plasma: Application to Pharmacokinetic Studies

Kiyotaka NAKAGAWA, Hiroyuki KUBOTA, Tsuyoshi TSUZUKI, Jun KARIYA, Toshiyuki KIMURA, Shinichi OIKAWA, Teruo MIYAZAWA

著者情報

キーワード: mulberry, 1-deoxynojirimycin, tandem mass spectrometry, absorption, human plasma

ジャーナルフリー早期公開

論文ID: 80200

DOI https://doi.org/10.1271/bbb.80200

この記事には本公開記事があります。

The final version of this article is now available: Vol. 72 (2008) , No. 8 p.2210

詳細

抄録

Mulberry 1-deoxynojirimycin (DNJ) is a potent α-glucosidase inhibitor. Although it is useful for the treatment of diabetes, the human absorption and metabolism of DNJ have never been characterized. We developed a method using hydrophilic interaction chromatography coupled with ion trap tandem mass spectrometry, and found that orally administered DNJ was absorbed into the blood and then excreted into the urine.

責任著者(Corresponding author)

J-STAGEへの登録はこちら（無料）