Missense Mutation of Abcg5 in Stroke-Prone Spontaneously Hypertensive Rats Does Not Influence Lymphatic Sitosterol Absorption Regardless of the Dose: Comparison with Wistar Rats

Tadateru HAMADA; Yoko KODAMA; Katsumi IMAIZUMI; Ikuo IKEDA

doi:10.1271/bbb.90537

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Missense Mutation of Abcg5 in Stroke-Prone Spontaneously Hypertensive Rats Does Not Influence Lymphatic Sitosterol Absorption Regardless of the Dose: Comparison with Wistar Rats

Tadateru HAMADA, Yoko KODAMA, Katsumi IMAIZUMI, Ikuo IKEDA

著者情報

キーワード: ATP binding cassette transporter G5 (ABCG5), ATP binding cassette transporter G8 (ABCG8), intestinal absorption, plant sterol, stroke-prone spontaneously hypertensive rat (SHRSP)

ジャーナルフリー早期公開

論文ID: 90537

DOI https://doi.org/10.1271/bbb.90537

この記事には本公開記事があります。

The final version of this article is now available: Vol. 73 (2009) , No. 12 p.2777

詳細

抄録

The lymphatic recovery of radiolabeled sitosterol administered in various amounts to the stomach was almost the same between stroke-prone spontaneously hypertensive rats (SHRSPs), a strain having a missense mutation in ATP binding cassette transporter g5 (Abcg5), and Wistar rats, a normal strain. The results suggest that the mutation of Abcg5 in SHRSPs, compared with Wistar rats, did not influence the ability for intestinal sitosterol absorption regardless of the dose.

責任著者(Corresponding author)

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