In Vitro and in Vivo Evaluation of the Efficacy of Bovine Colostrum against Human Rotavirus Infection

Mizuho INAGAKI; Mayumi YAMAMOTO; XIJIER; CAIRANGZHUOMA; Kenji UCHIDA; Hiroshi YAMAGUCHI; Mihoko KAWASAKI; Kousaku YAMASHITA; Tomio YABE; Yoshihiro KANAMARU

doi:10.1271/bbb.90862

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In Vitro and in Vivo Evaluation of the Efficacy of Bovine Colostrum against Human Rotavirus Infection

Mizuho INAGAKI, Mayumi YAMAMOTO, XIJIER, CAIRANGZHUOMA, Kenji UCHIDA, Hiroshi YAMAGUCHI, Mihoko KAWASAKI, Kousaku YAMASHITA, Tomio YABE, Yoshihiro KANAMARU

著者情報

キーワード: bovine colostrum, human rotavirus, infection, diarrhea, suckling mice

ジャーナルフリー早期公開

論文ID: 90862

DOI https://doi.org/10.1271/bbb.90862

この記事には本公開記事があります。

The final version of this article is now available: Vol. 74 (2010) , No. 3 p.680

詳細

抄録

We found that skimmed and concentrated bovine late colostrum (SCBLC) obtained from normal cows at 6–7 d after parturition exhibited high potency in inhibiting replication of human rotavirus (HRV) in vitro. Furthermore, prophylactic oral administration of SCBLC once before inoculation of HRV prevented the development of diarrhea in suckling mice in vivo. SCBLC from normal cows might be useful in the prevention of HRV-induced severe gastroenteritis in immunocompromised hosts.

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