5. Über die Oxydation des Lysozyms mit Perjodat

Abstract

Lysozyme was oxidized with sodium meta-periodate, and the following results were obtained from investigations of the process of oxidation and the changes of lytic activity and absorption spec-trum. The Iytic activity decreases during oxidation. Lysozyme oxidized under moderate conditions was obtained as crystals with 60% of the original activity. The decrea_??_e in lytic activity has a linear relationship to the lowering of the optical density at 280.5 mμu. This lowering being caused chiefly by the decomposition of tryptophan, it may be concluded that tryptophan residue seems to play an important role in lytic activity.