Studies on the Antibacterial and Antifungal Substances

Part I. On a New Antifungal Organic Mercurial, Methylmercurithioacetamide

Abstract

Nineteen new alkylmercurithio derivatives were synthesized, and their antibacterial and antifungal activities were studied in comparison with Thimerosal, a representative commercial mercurial disinfectant. All the substances tested showed stronger activities than the latter agent. Among them, methylmercurithioacetamide was recognized as the most suitable remedy for dermatomycosis because of its high solubility and stability in alcoholic solvents for tincture preparation, its good effect in the treatment of experimental trichophytosis of guinea pigs, its low, acute and chronic toxicities and its lack of clinical side effects.