Studies on Growth Inhibition of Hiochi-bacteria, Specific Saprophytes of Sake

Part VII. Structure of Muta-aspergillic Acid (1)

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The outline of this report has already been published as a short communication concerningmuta-aspergillic acid, C₁₁H₁₈N₂O₃, a new growth inhibitant against hiochi-bacteria.Deoxymuta-aspergillic acid, C₁₁H₁₈N₂O, reduction product of muta-aspergillic acid, was convertedto 2, 5-diketopiperazine, C₁₁H₂0N₂O₂, and this compound was shown to be leucyl-valineanhydride since on hydrolysis, it yielded leucine and valine. These results and physical andchemical data on muta-aspergillic acid led to draw the conclusion that formula (I) or (II) is the most possible structure for this antibiotic.