抄録
Effects of purine and pyrimidine analogues on growth and amino acid accumulation were studied using Aerobacter aerogenes No. 19-35 which produces L-valine in phosphaterich medium (PS-medium) and L-glutamic acid in phosphate-poor medium (PD-medium). The cell growth was inhibited in PS-medium containing purine and pyrimidine analogues. In PD-medium, 6-thiolpurine such as 6-mercaptopurine, 6-methylmercaptopurine and 6-thioguanine did not inhibit cell growth while other drugs did. The addition of 6-thiolpurine, especially 6-mercaptopurine, to PD-medium provoked the production of valine in place of L-glutamic acid. Cells are classified into two types by these characters: L-valine producing type and L-glutamic acid producing type. Such conversion phenomena seemed to occur only in strain No. 19-35, since other strains of A. aerogenes and E. coli producing valine did not show the conversion phenomenon when exposed to 6-thiolpurines.
