抄録
Anaerobic deamination of cyclohexylamine (CHA) by the intestinal microorganisms of rabbits was studied.
1. Urinary excretion of cyclohexanol (CHnol) in rabbits receiving CHA orally was suppressed by the oral administration of neomycin or metronidazole, although the effects were considerably different in individuals.
2. When CHA was incubated anaerobically with the cecal contents of rabbits receiving CHA in drinking water, the deaminated metabolites, cyclohexanone and CHnol were accumulated to various extents. Furthermore, cyclohexanone was converted to CHnol which was further metabolized to other compounds in the cecal contents.
3. Streptococcus faecalis, Escherichia coli, Clostridium sp. and Bacillus sp. were isolated from the cecal contents, and possessed the abilities to deaminate CHA or desulfate cyclamate anaerobically. These activities were maintained on subculturing and in the dried cells.
