EFFECTS OF SOME INHIBITORS ON THE METABOLISM OF GUINEA PIG BRAIN SLICES

抄録

The effects of inhibitors on the oxygen uptake, lactic acid formation and glucose utilization by guinea pig brain slices metabolizing aerobically with glucose as a substrate were studied. Inhibitions of oxygen uptake of brain slices under the normal conditions by some inhibitors were not so predominant, although under the effect of potassium they were very clearly observed. But if considered resting upon their effects on lactic acid formation and glucose utilization, the differences of the metabolic characters between in presence and in absence of the potassium effect were not clearly confirmed.
Many complicated factors to be considered upon understanding the results obtained in the brain slices using metabolic inhibitors were mentioned and discussed. From the considerations cited above, it might be thought that glucose would be metabolized aerobically through the glycolytic and citric acid cycle routes either in presence or in absence of the potassium effect in brain slices as seen in many other tissues.