生物物理
Online ISSN : 1347-4219
Print ISSN : 0582-4052
ISSN-L : 0582-4052
総説
プチダレドキシン結合による P450camの酸素添加反応の制御機構
当舎 武彦石森 浩一郎森島 績
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2005 年 45 巻 2 号 p. 78-83

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Structural changes in cytochrome P450 camphor monooxygenase (P450cam) upon the binding of the electron donor, putidaredoxin (Pdx), have been believed to be crucial for the P450cam catalysis. However, the regulation mechanism for the P450cam-catalyzed reaction by Pdx binding, so-called “effector function” of Pdx, was unclear due to the lack of the structural information on the Pdx-induced structural changes in P450cam. Here we summarize the recent progress in characterizing the Pdx-induced structural changes in P450cam by using NMR spectroscopy and site-directed mutagenesis. The current information would help us to understand the effector function of Pdx in the P450cam catalysis.

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© 2005 by THE BIOPHYSICAL SOCIETY OF JAPAN
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