生物物理
Online ISSN : 1347-4219
Print ISSN : 0582-4052
ISSN-L : 0582-4052
総説
Redoxセンサータンパク質,ヘム制御ホスホジエスエラーゼの構造と機能
黒河 博文吉村-鈴木 登紀子笹倉 由貴江渡部 美紀平田 智士田口 須恵五十嵐 城太郎佐上 郁子清水 透
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2005 年 45 巻 2 号 p. 84-89

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Heme-regulated phosphodiesterase from Escherichia coli (Ec DOS) is a novel PAS heme-sensor enzyme. Ec DOS is active in the Fe2+ heme-bound form, whereas it is inactive in the Fe3+ heme-bound form. To elucidate the mechanism of the redox-dependent heme-regulated catalysis, we examined spectroscopic and functional characters of site-directed and deletion mutant proteins. We also determined crystal structures of the wild type enzyme under various conditions. In this review, we summarized findings about heme-sensor proteins, PAS domain and phosphodiesterase in general and structure and function relationships of Ec DOS specifically.

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© 2005 by THE BIOPHYSICAL SOCIETY OF JAPAN
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