生物物理
Online ISSN : 1347-4219
Print ISSN : 0582-4052
ISSN-L : 0582-4052
解説
X線結晶構造解析と分子動力学シミュレーションで紐解く膜輸送体の分子機構
石谷 隆一郎道喜 慎太郎加藤 英明濡木 理
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2014 年 54 巻 2 号 p. 085-090

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Membrane transporters transport their substrates across the membrane, thereby contributing to the maintenance of the cellular environments. One of the largest superfamily of the membrane transporters is Major Facilitator Superfamily (MFS), and many of MFS transporters are involved in the cellular uptake of various compounds utilizing the proton motive force across the membrane. Although several crystal structures of MFS transporters have been reported so far, their active transport mechanism has still remained elusive. Proton-dependent oligopeptide transporter, POT, is a member of MFS, and is involved in the uptake of oligopeptides as well as peptide-like drugs. In this article, we explain the active transporter mechanism by POT based on our recent results of the structural and computational analyses.

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© 2014 by THE BIOPHYSICAL SOCIETY OF JAPAN
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