抄録
Cytoplasmic dynein is a minus-end-directed microtubule-based motor involving various cellular functions including intracellular transport, cell division, and neuronal migration. Recent studies have revealed that single molecules of cytoplasmic dynein do not display unidirectional movement as observed in intracellular transport, but diffuse along microtubules. This diffusive behavior is transitioned to the unidirectional movement via regulatory protein mediated mechanism or self-regulated mechanism. Here, we review the recent advances in the study of cytoplasmic dynein regulation.
