総説
構造解析へのハイブリッドアプローチ：電子顕微鏡とX線自由電子レーザーからの実験データの活用
2017 年 57 巻 2 号 p. 090-094
詳細
2017 年 57 巻 2 号 p. 090-094
Hybrid approaches combine computational modeling techniques with low-resolution structural data. Such approaches have proven to be powerful tools to obtain new 3D structural and dynamical information on biological systems. Currently, major applications focus on cryo-EM data. Methods and some applications to construct atomic structural models of new functional states will be reviewed. In addition, possible extension to data from X-ray free electron laser, which currently provides low-resolution data, will be discussed.
