生物物理
Online ISSN : 1347-4219
Print ISSN : 0582-4052
ISSN-L : 0582-4052
総説
In vivo心臓ナノイメージング法の開発
下澤 東吾小比類巻 生大山 廣太郎照井 貴子福田 紀男
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2019 年 59 巻 1 号 p. 009-013

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In vivo nano-imaging is today’s key technology for understanding cellular and molecular functions on a real-time basis in living organisms. In mammals, including humans, the heart sends blood to the lungs and to the rest of the body each time it beats, only under the in vivo conditions. However, to date, sarcomeric contractions, which are the basis of myocardial dynamic behavior, have not been directly observed in vivo due to technical hurdles. In this article, we describe our newly developed in vivo cardiac nano-imaging microscope for mice, and discuss recent, novel findings obtained under true physiologic conditions by using this cutting-edge technology.

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© 2019 by THE BIOPHYSICAL SOCIETY OF JAPAN
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