総説
レジオネラ病原因子輸送系の構造と機能
キーワード:
type IV secretion system,
Legionella,
virulence,
molecular assembly,
electron microscopy,
electron cryotomography
2019 年 59 巻 1 号 p. 014-017
詳細
2019 年 59 巻 1 号 p. 014-017
Pathogenic bacteria possess specialized secretion systems on their surface. These are nanomachines that aim to transport bacterial virulence factors into host cell cytosol. The type IV secretion systems, which are evolutionarily related to bacterial conjugation systems, have divergent biological functions and are classified into two subgroups, type IVA and type IVB. By using electron microscopy, we first identified the molecular structure of the core complex of the type IVB secretion system from human pathogen Legionella pneumophila. Comparative analyses with the type IVA secretion system revealed the characteristic molecular architecture of this unique nanomachine.
