総説
膜内切断プロテアーゼの基質認識・切断機構
キーワード:
intramembrane-cleaving protease,
S2P family protease,
zinc metalloprotease,
RIP,
stress response,
Escherichia coli
2019 年 59 巻 2 号 p. 079-083
詳細
2019 年 59 巻 2 号 p. 079-083
Intramembrane-cleaving proteases (I-CLiPs) are a unique class of proteases, which catalyze proteolysis of target membrane proteins within the lipid bilayer. I-CLiPs are found in all kingdoms of life and are involved in various cellular processes such as stress responses, lipid homeostasis, induction of apoptosis and bacterial virulence. RseP, an Escherichia coli I-CLiP, plays a critical role in the extracytoplasmic stress response essential for bacterial survival. In this review, I will summarize the results of our recent studies on the structure and function of RseP and propose a model of the substrate recognition and cleavage by this peculiar protease.
