生物物理
Online ISSN : 1347-4219
Print ISSN : 0582-4052
ISSN-L : 0582-4052
総説
生体分子モーター・キネシンの“散逸”を計測する
有賀 隆行富重 道雄水野 大介
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ジャーナル フリー

2019 年 59 巻 6 号 p. 300-304

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抄録

Molecular motors are nonequilibrium open systems that convert chemical energy to mechanical work. The nonequilibrium energetics of single molecule kinesin were investigated by measuring the motion of an attached probe particle and its response to external forces with optical tweezers. The sum of the heat dissipation estimated from the violation of the fluctuation-response relation and the output power was inconsistent with the input free energy rate, indicating that large internal dissipation exists. Here we introduce the theoretical basis of the dissipation measurement and our recent experimental results, discussing the physiological implications of the hidden dissipation in the kinesin motor.

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© 2019 by THE BIOPHYSICAL SOCIETY OF JAPAN
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