総説
ゲノムの3次元高次分子構造を解く
キーワード:
genome,
nucleosome,
3D modeling,
next generation sequencing,
Hi-C,
molecular dynamics simulation
2019 年 59 巻 6 号 p. 305-309
詳細
2019 年 59 巻 6 号 p. 305-309
The nucleosome arrangement in the genome is an important long-standing problem in biology. To address this, we recently developed a new technology for investigating 3D positions and orientations of nucleosomes across the genome. Analysis of the yeast genome revealed that the nucleosome arrangement is composed of two basic structures, named α-tetrahedron and β-rhombus. Further, we discovered that the nucleosome arrangement is distinct at every genomic locus depending on epigenetic regulation. The results provide the molecular basis of transcriptional and epigenetic events on the genome.
