Protective effects of heat-killed Lactococcus lactis subsp. lactis BF3, isolated from the intestine of chum salmon, in a murine model of DSS-induced inflammatory bowel disease

Toru NAKATA; Shino HIRANO; Yasushi YOKOTA; Hajime TAKAHASHI; Bon KIMURA; Takashi KUDA; Tadashi ETO; Michiko KATO

doi:10.12938/bmfh.2016-007

Note

Protective effects of heat-killed Lactococcus lactis subsp. lactis BF3, isolated from the intestine of chum salmon, in a murine model of DSS-induced inflammatory bowel disease

Toru NAKATA, Shino HIRANO, Yasushi YOKOTA, Hajime TAKAHASHI, Bon KIMURA, Takashi KUDA, Tadashi ETO, Michiko KATO

著者情報

Toru NAKATA
Department of Food Science and Technology, Tokyo University of Marine Science and Technology, Tokyo 108-8477, Japan
Shino HIRANO
Department of Food Science and Technology, Tokyo University of Marine Science and Technology, Tokyo 108-8477, Japan
Yasushi YOKOTA
Department of Food Science and Technology, Tokyo University of Marine Science and Technology, Tokyo 108-8477, Japan
Hajime TAKAHASHI
Department of Food Science and Technology, Tokyo University of Marine Science and Technology, Tokyo 108-8477, Japan
Bon KIMURA
Department of Food Science and Technology, Tokyo University of Marine Science and Technology, Tokyo 108-8477, Japan
Takashi KUDA
Department of Food Science and Technology, Tokyo University of Marine Science and Technology, Tokyo 108-8477, Japan
Tadashi ETO
Nippon Barrier Free Co., Ltd., Tokyo 101-0051, Japan
Michiko KATO
Nippon Barrier Free Co., Ltd., Tokyo 101-0051, Japan

キーワード: Lactococcus lactis, inflammatory bowel disease, mice

ジャーナルフリー

2016 年 35 巻 3 号 p. 137-140

DOI https://doi.org/10.12938/bmfh.2016-007

Browse “Advance online publication” version

詳細

抄録

Oxidative stress is considered an etiological factor responsible for several symptoms of inflammatory bowel disease (IBD). In vitro anti-inflammatory activities of heat-killed Lactococcus lactis subsp. lactis BF3 have been reported. In this study, the anti-inflammatory effect of these cells was examined using a dextran sodium sulphate (DSS)-induced murine IBD model. Administration of heat-killed L. lactis BF3 via drinking water suppressed the IBD symptoms, such as shortening of colon length, damage to the colon mucosa as observed under the microscope, and spleen enlargement. This result suggests that heat-killed L. lactis BF3 has the potential to treat IBD.

責任著者(Corresponding author)

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