Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
Regular Articles
Anti-androgenic Activity of Myricae Cortex—Isolation of Active Constituents from Bark of Myrica rubra
Hideaki MATSUDAMiho YAMAZAKIKeizo MATSUOYusuke ASANUMAMichinori KUBO
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2001 年 24 巻 3 号 p. 259-263

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The aqueous ethanol extract of Myricae Cortex (bark of Myrica rubra SIEB. et ZUCC., Myricaceae) showed in vitro testosterone 5α-reductase inhibitory activity and in vivo anti-androgenic activity using growth of flank organ in castrated Syrian hamsters and/or hair regrowth after shaving in testosterone-treated C57Black/6CrSlc mice. Three constituents, myricanone, myricanol, and myricetin were identified as the main active principles.
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© 2001 The Pharmaceutical Society of Japan
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