Identification of 16α,19-Dihydroxyandrostenedione in the Serum of Pregnant Women by Gas Chromatography-Mass Spectrometry

Mitsuteru NUMAZAWA; Satoshi SATOH; Masao NAGAOKA; Hideo HONJO; Yoshio OSAWA

doi:10.1248/bpb.24.947

Notes

Identification of 16α,19-Dihydroxyandrostenedione in the Serum of Pregnant Women by Gas Chromatography-Mass Spectrometry

Mitsuteru NUMAZAWA, Satoshi SATOH, Masao NAGAOKA, Hideo HONJO, Yoshio OSAWA

Author information

Keywords: 16α,19-dihydroxy androgen, serum concentration, pregnant woman, estriol formation, feto-placental unit

JOURNAL FREE ACCESS

2001 Volume 24 Issue 8 Pages 947-949

DOI https://doi.org/10.1248/bpb.24.947

Details

Abstract

16α,19-Dihydroxyandrostenedione [16α,19-(OH)₂ AD], a potential precursor of estriol, was identified in the serum of pregnant women by gas chromatography-mass spectrometry (GC-MS). Preliminary study indicated that the average serum concentration of 16α,19-(OH)₂ AD in 10 normal pregnant women was 154.2±20 pg/ml. In contrast, the serum concentration of 16α,19-dihydroxydehydroepiandrosterone was less than the detection limit (30 pg/ml) of the GC-MS method.

Corresponding author

Register with J-STAGE for free!