Antidiabetic Activity of the Rhizoma of Anemarrhena asphodeloides and Active Components, Mangiferin and Its Glucoside

Toshihiro MIURA; Hiroyuki ICHIKI; Naoki IWAMOTO; Motoshi KATO; Masayoshi KUBO; Hiroshi SASAKI; Minoru OKADA; Torao ISHIDA; Yutaka SEINO; Keiichiro TANIGAWA

doi:10.1248/bpb.24.1009

Regular Articles

Antidiabetic Activity of the Rhizoma of Anemarrhena asphodeloides and Active Components, Mangiferin and Its Glucoside

Toshihiro MIURA, Hiroyuki ICHIKI, Naoki IWAMOTO, Motoshi KATO, Masayoshi KUBO, Hiroshi SASAKI, Minoru OKADA, Torao ISHIDA, Yutaka SEINO, Keiichiro TANIGAWA

著者情報

キーワード: Anemarrhena asphodeloides, mangiferin, antidiabetic activity, KK-Ay mouse

ジャーナルフリー

2001 年 24 巻 9 号 p. 1009-1011

DOI https://doi.org/10.1248/bpb.24.1009

詳細

抄録

The antidiabetic activity of the rhizoma of Anemarrhena asphodeloides was investigated in KK-Ay mice, an animal model of genetic type 2 diabetes. The water extract of the rhizoma (AA) (90 mg/kg) reduced blood glucose levels from 570±29 to 401±59 mg/dl 7 h after oral administration (p<0.05) and also tended to reduce serum insulin levels in KK-Ay mice. AA-treated KK-Ay mice had significantly reduced blood glucose levels in an insulin tolerance test. Based on these results, the antidiabetic mechanism of AA may be due to decreased insulin resistance. In addition, the active components of AA were confirmed to be mangiferin and its glucoside.

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