Anti-HIV Active Petrosins from the Marine Sponge Petrosia similis

Thirumani Venkateshwar Goud; Natala Srinivasa Reddy; Navath Raghavendra Swamy; Tejomoortula Siva Ram; Yenamandra Venkateswarlu

doi:10.1248/bpb.26.1498

Notes

Anti-HIV Active Petrosins from the Marine Sponge Petrosia similis

Thirumani Venkateshwar Goud, Natala Srinivasa Reddy, Navath Raghavendra Swamy, Tejomoortula Siva Ram, Yenamandra Venkateswarlu

著者情報

キーワード: petrosin, anti-HIV activity, antiviral activity, giant cell, MAGI, reverse transcriptase

ジャーナルフリー

2003 年 26 巻 10 号 p. 1498-1501

DOI https://doi.org/10.1248/bpb.26.1498

詳細

抄録

A marine sponge Petrosia similis afforded two compounds which belongs to bis-quinolizidine alkaloids namely, petrosin (1) and petrosin-A (2), respectively. Petrosin (1) and petrosin-A (2) showed anti-HIV inhibition with IC₅₀ values of 41.3 and 52.9 μm respectively. MAGI cell assays indicated that the compounds inhibited early steps of HIV replication. In extracellular HIV-1 Reverse Transcriptase inhibition assay petrosin and petrosin-A inhibited HIV-1 RT at 10.6 and 14.8 μm. This is the first report of petroisns with anti-HIV activity.

責任著者(Corresponding author)

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