Isolation of Nitrophenols from Diesel Exhaust Particles (DEP) as Vasodilatation Compounds

Yoki Mori; Kazuyuki Kamata; Noriko Toda; Hideyuki Hayashi; Koh-ichi Seki; Shinji Taneda; Shin Yoshino; Akiyo Sakushima; Masakatsu Sakata; Akira K. Suzuki

doi:10.1248/bpb.26.394

Communications to the Editor

Isolation of Nitrophenols from Diesel Exhaust Particles (DEP) as Vasodilatation Compounds

Yoki Mori, Kazuyuki Kamata, Noriko Toda, Hideyuki Hayashi, Koh-ichi Seki, Shinji Taneda, Shin Yoshino, Akiyo Sakushima, Masakatsu Sakata, Akira K. Suzuki

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Keywords: diesel exhaust particle, nitrophenol, vasodilatation

JOURNAL FREE ACCESS

2003 Volume 26 Issue 3 Pages 394-395

DOI https://doi.org/10.1248/bpb.26.394

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Abstract

The compounds in diesel exhaust particles (DEP) that are responsible for vasodilatation were isolated and characterized for the first time. From benzene extract of DEP, 2-methyl-4-nitrophenol, 3-methyl-4-nitrophenl and 4-nitrophenol were isolated, and their vasodilatation activities were confirmed. 3-methyl-4-nitrophenol caused dilatation of rat thoracic artery, and the other two nitrophenols, also showed vasodilatation activities.

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