Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
Notes
Antinociceptive Profile of 2-Phenylselenenyl-1,8-cineole in Mice
Damião Pergentino de SousaEllen RaphaelUrsula BrocksomTimothy John Brocksom
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2004 年 27 巻 6 号 p. 910-911

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2-Phenylselenenyl-1,8-cineole (PSC) increased both the pentobarbital-induced sleeping time and the reaction time (up to 2 h) in the tail immersion method. PSC also caused dose-dependent inhibition of acetic acid induced writhing with maximum inhibition of 93.4% and was approximately 8.5-fold more potent than 1,8-cineole. These findings show that PSC presents sedative effect and significant antinociceptive activity.
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© 2004 The Pharmaceutical Society of Japan
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