Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
Regular Articles
Cognitive Improving and Cerebral Protective Effects of Acylated Oligosaccharides in Polygala tenuifolia
Yukinobu IkeyaShigefumi TakedaMitsuo TunakawaHumito KarakidaKouin TodaTakuji YamaguchiMasaki Aburada
ジャーナル フリー

2004 年 27 巻 7 号 p. 1081-1085


We studied the cognitive improving and cerebral protective constituents in the roots of Polygala tenuifolia WILLDENOW, a well-known Chinese traditional medicine prescribed for amnesia, neurasthenia, palpitation, noctural emission and insomnia. Tenuifoliside B (1), which is one of the acylated oligosaccharides in the roots of P. tenuifolia, showed the cerebral protective effect on potassium cyanide (KCN)-induced anoxia in mice, widely used as an animal model for cerebrovascular disease, and also had an ameliorative effect on the scopolamine-induced impairment of performance in passive avoidance task in rats. Compound 1 significantly enhanced oxotremorine-induced tremors in mice, suggesting that it ameliorated the scopolamine-induced impairment of passive avoidance response by enhancing the cholinergic system. These findings show that compound 1 has cognitive improving and cerebral protective effects.

© 2004 The Pharmaceutical Society of Japan
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