Inhibitory Effect of Traditional Turkish Folk Medicines on Aldose Reductase (AR) and Hematological Activity, and on AR Inhibitory Activity of Quercetin-3-O-methyl Ether Isolated from Cistus laurifolius L.

Shigeki Enomoto; Yoshihito Okada; Aysegül Güvenc; Ceyda Sibel Erdurak; Maskut Coşkun; Toru Okuyama

doi:10.1248/bpb.27.1140

Notes

Inhibitory Effect of Traditional Turkish Folk Medicines on Aldose Reductase (AR) and Hematological Activity, and on AR Inhibitory Activity of Quercetin-3-O-methyl Ether Isolated from Cistus laurifolius L.

Shigeki Enomoto, Yoshihito Okada, Aysegül Güvenc, Ceyda Sibel Erdurak, Maskut Coşkun, Toru Okuyama

著者情報

キーワード: Cistus laurifolius, complications of diabetes, quercetin-3-O-methyl ether, human aldose reductase, platelet aggregation, blood coagulation

ジャーナルフリー

2004 年 27 巻 7 号 p. 1140-1143

DOI https://doi.org/10.1248/bpb.27.1140

J-STAGE : bpb 27 12 pp.2052-2052

詳細

抄録

The inhibitory effects of 40 extracts prepared from 38 traditional Turkish folk medicines on human aldose reductase (h-AR) and hematological activity were investigated. Seven plants containing 5 species of Cistus genus exhibited a potent inhibition of h-AR. Ferulago amani (root) inhibited the platelet aggregation induced by sodium arachidonate, while C. laurifolius (fruit) was found to possess strong inhibition in the blood coagulation assay. An AcOEt extract derived from the leaf of C. laurifolius was purified to isolate three known flavonoids. The activity of one, quercetin-3-O-methyl ether, was found to be as potent as that of eparlestat, which is known to be a remedy for treating complications associated with diabetes.

責任著者(Corresponding author)

J-STAGEへの登録はこちら（無料）