A Novel Immunomodulator, FTY720, Prevents Spontaneous Dermatitis in NC/Nga Mice

Takeyuki Kohno; Takumi Tsuji; Kaori Hirayama; Kazuhito Watabe; Akiko Matsumoto; Tomoko Kohno; Tetsuro Fujita

doi:10.1248/bpb.27.1392

Regular Articles

A Novel Immunomodulator, FTY720, Prevents Spontaneous Dermatitis in NC/Nga Mice

Takeyuki Kohno, Takumi Tsuji, Kaori Hirayama, Kazuhito Watabe, Akiko Matsumoto, Tomoko Kohno, Tetsuro Fujita

著者情報

キーワード: FTY720, atopic dermatitis, NC/Nga mouse

ジャーナルフリー

2004 年 27 巻 9 号 p. 1392-1396

DOI https://doi.org/10.1248/bpb.27.1392

詳細

抄録

Oral administration of a novel immunomodulator, FTY720 (0.1 mg/kg, once a week), completely prevented the spontaneous development of dermatitis in NC/Nga mice. It also strongly suppressed hyper IgE production in serum, as well as hypertrophy of the epidermis and the degranulation of granulocytes in the skin, all of which were observed in mice in which the dermatitis had become established. These results strongly suggest that FTY720 is a promising candidate for treatment of human atopic dermatitis.

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