Antiproliferative Constituents from Umbelliferae Plants VII. Active Triterpenes and Rosmarinic Acid from Centella asiatica

Miyako Yoshida; Masahiro Fuchigami; Tsuneatsu Nagao; Hikaru Okabe; Kazuhisa Matsunaga; Jiro Takata; Yoshiharu Karube; Ryota Tsuchihashi; Junei Kinjo; Kunihide Mihashi; Toshihiro Fujioka

doi:10.1248/bpb.28.173

Notes

Antiproliferative Constituents from Umbelliferae Plants VII. Active Triterpenes and Rosmarinic Acid from Centella asiatica

Miyako Yoshida, Masahiro Fuchigami, Tsuneatsu Nagao, Hikaru Okabe, Kazuhisa Matsunaga, Jiro Takata, Yoshiharu Karube, Ryota Tsuchihashi, Junei Kinjo, Kunihide Mihashi, Toshihiro Fujioka

著者情報

キーワード: Centella asiatica, antiproliferative activity, Umbelliferae, triterpene

ジャーナルフリー

2005 年 28 巻 1 号 p. 173-175

DOI https://doi.org/10.1248/bpb.28.173

詳細

抄録

The antiproliferative constituents in the MeOH extract from the aerial parts of Centella asiatica were investigated. Activity-guided fractionation of MeOH extract resulted in the isolation of ursolic acid lactone, ursolic acid, pomolic acid, 2α,3α-dihydroxyurs-12-en-28-oic acid, 3-epimaslinic acid, asiatic acid, corosolic acid, and rosmarinic acid. Antiproliferative activity of the isolated compounds against human gastric adenocarcinoma (MK-1), human uterine carcinoma (HeLa), and murine melanoma (B16F10) cells was estimated.

責任著者(Corresponding author)

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