Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
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Antispasmodic Activity of Fractions and Cynaropicrin from Cynara scolymus on Guinea-Pig Ileum
Fernanda EmendörferFabiane EmendörferFernanda BellatoVânia Floriani NoldinValdir Cechinel-FilhoRosendo Augusto YunesFranco Delle MonacheAlcíbia Maia Cardozo
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2005 年 28 巻 5 号 p. 902-904

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This study describes the antispasmodic activity of some fractions and cynaropicrin, a sesquiterpene lactone from Cynara scolymus, cultivated in Brazil, against guinea-pig ileum contracted by acetylcholine. The dichloromethane fraction showed the most promising biological effects, with an IC50 of 0.93 (0.49—1.77) mg/ml. Its main active component, the sesquiterpene lactone cynaropicrin, exhibited potent activity, with IC50 of 0.065 (0.049—0.086) mg/ml, being about 14-fold more active than dichloromethane fraction and having similar potency to that of papaverine, a well-known antispasmodic agent. The results confirm the popular use of artichoke for the treatment of gastrointestinal disturbances, and encourage new studies on this compound, in order to obtain new antispasmodic agents.

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© 2005 The Pharmaceutical Society of Japan
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