Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
Regular Articles
Pharmacokinetics of Guanfu Base I, an Active Metabolite of Guanfu Base A, in Rats
Xiaotian LiGuangji WangSujun WangJianguo SunJinghan Liu
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キーワード: guanfu base I, pharmacokinetics, LC-MS
ジャーナル フリー

2005 年 28 巻 8 号 p. 1363-1365

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A liquid chromatographic-mass spectrometric (LC-MS) method was developed and validated for determination of guanfu base I (GFI), and the pharmacokinetics of GFI in Sprague-Dawley rats was examined. The method was linear in the 0.05—20 μg/ml concentration range (r=0.9994). The recovery of guanfu base I was more than 80%. The intraday and interday precision, expressed as the relative standard deviation (RSD), was generally good (<15%). After i.v. dosing, plasma GFI concentration declined in a bi-phasic manner with a terminal elimination half-life of 2.49 h. The total plasma clearance values was 1.46 l/h/kg. After oral dosing, the plasma GFI concentration reached a maximum within 0.5 h. The absolute bioavailability of GFI was 71.31%.

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© 2005 The Pharmaceutical Society of Japan
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