7-Hydroxy-3-(4-hydroxybenzyl)chroman and Broussonin B: Neurotrophic Compounds, Isolated from Anemarrhena asphodeloides B<small>UNGE</small>, Function as Proteasome Inhibitors

Sachiko Tsukamoto; Takeshi Wakana; Keiichirou Koimaru; Takushi Yoshida; Mako Sato; Tomihisa Ohta

doi:10.1248/bpb.28.1798

Notes

7-Hydroxy-3-(4-hydroxybenzyl)chroman and Broussonin B: Neurotrophic Compounds, Isolated from Anemarrhena asphodeloides BUNGE, Function as Proteasome Inhibitors

Sachiko Tsukamoto, Takeshi Wakana, Keiichirou Koimaru, Takushi Yoshida, Mako Sato, Tomihisa Ohta

著者情報

キーワード: Anemarrhena asphodeloides, neurotrophic, proteasome inhibitory activity

ジャーナルフリー

2005 年 28 巻 9 号 p. 1798-1800

DOI https://doi.org/10.1248/bpb.28.1798

詳細

抄録

The extract of Anemarrhenae Rhizoma (rhizomes of Anemarrhena asphodeloides BUNGE) showed neurotrophic activity toward rat pheochromocytoma (PC-12) cells. Bioassay-guided purification afforded four compounds, 2,6,4′-trihydroxy-4-methoxybenzophenone (1), 7-hydroxy-3-(4-hydroxybenzyl)chroman (2), broussonin B (3), and cis-hinokiresinol (4). Compounds 1—3 induced neurite outgrowth in PC-12 cells at concentration of 50 μg/ml, while 4 was less active. In addition, compounds 2—4 showed moderate inhibitory activities against a chymotrypsin-like activity of the proteasome.

責任著者(Corresponding author)

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