8-Hydroxydihydrochelerythrine and 8-Hydroxydihydrosanguinarine with a Potent Acetylcholinesterase Inhibitory Activity from Chelidonium majus L.

Kyung-Mi Cho; Ick-Dong Yoo; Won-Gon Kim

doi:10.1248/bpb.29.2317

Notes

8-Hydroxydihydrochelerythrine and 8-Hydroxydihydrosanguinarine with a Potent Acetylcholinesterase Inhibitory Activity from Chelidonium majus L.

Kyung-Mi Cho, Ick-Dong Yoo, Won-Gon Kim

著者情報

キーワード: Chelidonium majus L., acetylcholinesterase, 8-hydroxydihydrochelerythrine, 8-hydroxydihydrosanguinarine

ジャーナルフリー

2006 年 29 巻 11 号 p. 2317-2320

DOI https://doi.org/10.1248/bpb.29.2317

詳細

抄録

Ethanol extract of the aerial portion of Chelidonium majus L. inhibited acetylcholinesterase (AChE) activity without a significant inhibition of butyrylcholinesterase (BuChE). Using mass spectrometry and NMR studies, three active constituents were isolated and identified: 8-hydroxydihydrochelerythrine (1), 8-hydroxydihydrosanguinarine (2), and berberine (3). Compounds 1—3 showed potent inhibitory activity against AChE, with IC₅₀ (μM) values of 0.61—1.85. Compound 1 exhibited competitive and selective inhibition for AChE.

責任著者(Corresponding author)