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Cinnamaldehyde Induces Endothelium-Dependent and -Independent Vasorelaxant Action on Isolated Rat Aorta
Ayano YanagaHirozo GotoTakako NakagawaHiroaki HikiamiNaotoshi ShibaharaYutaka Shimada
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Volume 29 (2006) Issue 12 Pages 2415-2418

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Abstract

The vasorelaxant effect of cinnamaldehyde, one of the major oil components in Cinnamomi Cortex, was studied using isolated rat aorta. Cinnamaldehyde at final concentrations of 1 μM to 1 mM showed dose-dependent relaxation of the rat aorta contracted by treatment with prostaglandin F, norepinephrine or KCl. In addition, cinnamaldehyde relaxed prostaglandin F-precontracted aortic rings with endothelium and without endothelium, with the latter being significantly less sensitive than the former. Relaxation induced by cinnamaldehyde with endothelium was significantly inhibited by NG-nitro-L-arginine methyl ester (L-NAME), while nonselective cyclooxygenase inhibitor (indomethacin), β-adrenergic receptor blocker (propranolol), an inhibitor of phosphodiesterase (theophylline), a delayed rectifier K+ channel blocker (tetraethyl ammonium chloride), or an ATP-sensitive K+ channel blocker (glibenclamide) did not reduce the relaxation induced by cinnamaldehyde with endothelium treated by L-NAME. Conversely, aorta pretreatment with L-NAME and theophylline increased the relaxation by cinnamaldehyde significantly compared to aorta pretreatment with only L-NAME. Furthermore, cinnamaldehyde significantly inhibited Ca2+-induced contraction. These results suggested that the vasorelaxant effects of cinnamaldehyde were derived from both endothelium-dependent and -independent effects. Endothelium-dependent relaxation is affected by nitric oxide, and one of the mechanisms of endothelium-independent relaxation is thought to be influenced by the blocking of Ca2+ channels.

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© 2006 The Pharmaceutical Society of Japan
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