Human ACAT-1 and ACAT-2 Inhibitory Activities of Pentacyclic Triterpenes from the Leaves of Lycopus lucidus T<small>URCZ</small>.

Woo Song Lee; Kyung-Ran Im; Yong-Dae Park; Nack-Do Sung; Tae-Sook Jeong

doi:10.1248/bpb.29.382

Notes

Human ACAT-1 and ACAT-2 Inhibitory Activities of Pentacyclic Triterpenes from the Leaves of Lycopus lucidus TURCZ.

Woo Song Lee, Kyung-Ran Im, Yong-Dae Park, Nack-Do Sung, Tae-Sook Jeong

著者情報

キーワード: Lycopus lucidus, acyl-CoA: cholesterol acytransferase (ACAT), pentacyclic triterpene, atherosclerosis

ジャーナルフリー

2006 年 29 巻 2 号 p. 382-384

DOI https://doi.org/10.1248/bpb.29.382

詳細

抄録

Acyl-CoA: cholesterol acyltransferase (ACAT) catalyzes the acylation of cholesterol to cholesteryl ester with long chain fatty acids and ACAT inhibition is a useful strategy for treating hypercholesterolemia or atherosclerosis. Pentacyclic triterpenes, ursolic acid (1), oleanolic acid (2), and betulinic acid (3) were isolated from the methanol extracts of the leaves of Lycopus lucidus TURCZ. by bioassay-guided fractionation. The structures of compounds 1—3 were elucidated by their spectroscopic data analysis. Among them, betulinic acid (3) exhibited more potent human ACAT-1 and ACAT-2 inhibitory activities with IC₅₀ values of 16.2±0.6 and 28.8±1.3 μM, respectively.

責任著者(Corresponding author)

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