Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
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5α-Reductase Inhibitory Effect of Triterpenoids Isolated from Ganoderma lucidum
Jie LiuKenji KurashikiKuniyoshi ShimizuRyuichiro Kondo
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2006 Volume 29 Issue 2 Pages 392-395

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Abstract

5α-Reductase inhibitory activity-guided fractionation of the EtOH extract of the fruiting body of Ganoderma lucidum (LEYSS.:FR.) KARST. (Ganodermataceae), which is called Reishi, or Mannentake in Japan and Lingzhi in China, led to the isolation of two active compounds which were ganoderic acid DM and 5α-lanosta-7,9(11),24-triene-15α,26-dihydroxy-3-one with an IC50 of 10.6 μM and 41.9 μM respectively. A carboxyl group of side chain of ganoderic acid DM is essential to elicit the inhibitory activity because of much less activity of its methyl ester.

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© 2006 The Pharmaceutical Society of Japan
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