Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
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Growth Inhibition of Stilbenoids in Welwitschiaceae and Gnetaceae through Induction of Apoptosis in Human Leukemia HL60 Cells
Ibrahim Iliya, Yukihiro Akao, Kenji Matsumoto, Yoshihito Nakagawa, Ali Zulfiqar, Tetsuro Ito, Masayoshi Oyama, Hiroko Murata, Toshiyuki Tanaka, Yoshinori Nozawa, Munekazu Iinuma
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Keywords: gnemonol G, gnetin I, stilbenoid, Welwitschiaceae, Gnetaceae, apoptosis
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2006 Volume 29 Issue 7 Pages 1490-1492

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Abstract
Fifty-six stilbenoids isolated from the families of Welwitschiaceae and Gnetaceae were screened for growth inhibitory activity against HL60 cells, and two compounds (gnemonol G and gnetin I) among them exhibited a strong activity with IC50 of 10.0 μM and 12.2 μM at 48 h incubation, respectively. The growth suppression by gnemonol G and gnetin I was found to be in part due to apoptosis which was assessed by morphological findings such as nuclear condensation and fragmentation, and DNA ladder formation in human leukemia HL60 cells.
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© 2006 The Pharmaceutical Society of Japan
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