Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
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The Inhibitory Effects of Eckol and Dieckol from Ecklonia stolonifera on the Expression of Matrix Metalloproteinase-1 in Human Dermal Fibroblasts
Min-Jeong JoeSu-Nam KimHye-Young ChoiWoon-Seob ShinGab-Man ParkDong-Won KangYong Kee Kim
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2006 Volume 29 Issue 8 Pages 1735-1739


In order to develop new anti-photoaging agents, we examined the inhibitory effects of 29 seaweed extracts on transcriptional activities of NF-κB and AP-1, and MMP-1 expression. The extracts from 3 species of Alariaceae, Eisenia bicyclis, Ecklonia cava and Ecklonia stolonifera, have showed strong inhibition of both NF-κB and AP-1 reporter activity, which were well correlated with their abilities to inhibit MMP-1 expression. In addition, MMP-1 expression was dramatically attenuated by treatment with eckol or dieckol which were purely isolated from E. stolonifera, indicating that these compounds are active principles to inhibit MMP-1 expression in human dermal fibroblasts. Taken together, our data demonstrate the inhibitory effect of eckol and dieckol from Ecklonia species on MMP-1 expression in human dermal fibroblasts and provide a possibility to develop as an agent for the prevention and treatment of skin aging.

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© 2006 The Pharmaceutical Society of Japan
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